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A new potential radiosensitizer: ammonium persulfate modified WCNTs Nature Precedings
Jian-She Yang; Bo-Zhang Yu; Wen-Xin Li.
Radiotherapy plays a very important role in cancer treatment. Radiosensitizers have been widely used to enhance the radiosensitivity of cancer cells at given radiations. Here we fabricate multi-walled carbon nanotubes with ammonium persulfate, and get very short samples with 30-50 nanometer length. Cell viability assay show that f-WCNTs induce cell death significantly. We hypothesize that free radicals originated from hydroxyl and carbonyl groups on the surface of f-WCNTs lead cell damage.
Tipo: Manuscript Palavras-chave: Biotechnology; Cancer; Chemistry.
Ano: 2007 URL: http://precedings.nature.com/documents/1421/version/1
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Polyethylenimine-Modified Multiwalled Carbon Nanotubes for Plasmid DNA Gene Delivery Nature Precedings
Bo-Zhang Yu; Ji-Fei Ma; Wen-Xin Li.
An efficient molecular delivery technique based on the transporting high-molecular-weight PEI 600K-modified multiwalled carbon nanotubes (PEI 600K-MWCNTs) into cell membranes is reported. The PEI 600K-MWCNTs exhibit low cytotoxicity and its associated plasmid DNA (pDNA) is delivered to cells efficiently, and the green fluorescent protein (GFP) levels up to 18 times higher than that of naked DNA were observed.
Tipo: Manuscript Palavras-chave: Biotechnology; Cancer; Chemistry.
Ano: 2009 URL: http://precedings.nature.com/documents/2753/version/1
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